| Day | Time | Opponent | Score | Record | ||||
| August | ||||||||
| 28 | 8:00 PM | vs. | Kentucky Christian University | W-56-12 | 0-0 1-0 | |||
| at Morehead State University | ||||||||
| September | ||||||||
| 13 | 1:00 PM | @ | Newport News | W-42-0 | 0-0 2-0 | |||
| Listen Live Live Stats | ||||||||
| * | 20 | 6:00 PM | vs. | West Virginia Tech | W-62-33 | 1-0 3-0 | ||
| Listen Live Live Stats | ||||||||
| 27 | 1:30 PM | vs. | Lambuth University | L-40-51 | 1-0 3-1 | |||
| Listen Live Live Stats | ||||||||
| October | ||||||||
| * | 4 | 1:30 PM | @ | Georgetown College | W-35-28 | 2-0 4-1 | ||
| * | 11 | 1:30 PM | vs. | Campbellsville University | W-61-41 | 3-0 5-1 | ||
| Listen Live Live Stats | ||||||||
| 18 | 2:30 PM | @ | Cumberland Univ. | W-27-14 | 3-0 6-1 | |||
| Listen Live Live Stats | ||||||||
| * | 25 | 1:30 PM | @ | University of Pikeville | W-14-6 | 4-0 7-1 | ||
| Wise ranked 11th in NAIA | ||||||||
| November | ||||||||
| * | 1 | 1:30 PM | vs. | Union College | L-34-37 | 4-1 7-2 | ||
| Live Video Listen Live Live Stats | ||||||||
| * | 8 | 1:30 PM | @ | Cumberlands | L-37-56 | 4-2 7-3 | ||
| Senior Day - MSC East Division Champions | ||||||||
| 15 | 1:30 PM | vs. | Faulkner University | W-47-12 | 4-2 8-3 | |||
| Live Video Listen Live Live Stats | ||||||||